InterOss® Collagen

Interconnected Porous Structure, Pliable, Moldable

InterOss® Collagen

InterOss® Collagen is an organic hydroxyapatite-collagen composite for use in periodontal, oral, and maxillofacial surgery. It is a combination of 90% bovine granules and 10% porcine collagen fibers molded in a block and plug form. InterOss® granules exhibits a natural bone mineralized structure, similar to human bone, and provides an osteoconductive environment for the ingrowth of the adjacent viable bone. Its excellent porosity allows for the grafting material channel to act as a conduit for the exchange of body fluids, growth factors while allowing cells to guide bone formation. Highly purified collagen facilitates the adaptation of the InterOss® granules to the defect site allowing exceptional handling and ease of use.


InterOss® Collagen

InterOss® Collagen is available in five sizes.

IOC-50 IOC-100 IOC-250 IOC-350 IOC-500
Weight 50mg 100mg 250mg 350mg 500mg

Indications of Use

InterOss® Collagen are recommended for:

  • Filling of periodontal defects
  • Elevation of the maxillary sinus floor
  • Augmentation or reconstructive treatment of the alveolar ridge
  • Filling of defects after root resection, apicoectomy, and cystectomy
  • Filling of extraction sockets to enhance preservation of the alveolar ridge
  • Filling of peri-implant defects in conjunction with products
    intended for Guided Bone Regeneration (GBR)
  • Filling of periondontal defects in conjunction with products
    intended for Guided Tissue Regeneration (GTR) and Guided
    Bone Regeneration (GBR)


InterOss® Collagen has 10% of collagen since collagen plays an important element of extracellular matrix which regulates cell functions. InterOss® Collagen is pliable and moldable making it easy to handle.

InterOss® Collagen is validated and documented in case of studies through clinicians involving procedures such as horizontal/vertical augmentation, sinus augmentation, and sinus elevation.

Disclaimer: InterOss® Collagen is registered or available in a selected country/region. Please check with a SigmaGraft representative for availability and further information



If you are a distributor or clinician and have questions about the product, please submit an inquiry below.

    Customer Information

    Product Inquiry